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Management of Asthma in Adults and Children

Classification of Severity and Therapy Recommendations*

Step 1: Mild Intermittent Step 2: Mild Persistent Step 3: Moderate Persistent Step 4: Severe Persistent
Symptoms
  • Symptoms less than or equal to 2 times a week
  • Asymptomatic and normal PEF between exacerbations
  • Exacerbations brief (from a few hours to a few days); intensity may vary
  • Symptoms greater than 2 times a week but less than 1 time a day
  • Exacerbations may affect activity
  • Daily Symptoms
  • Daily use of inhaled short-acting beta2-agaonists
  • Exacerbations affect activity
  • Exacerbations greater than or equal to 2 times a week; may last days
  • Continual Symptoms
  • Limited Physical Activity
  • Frequent exacerbations
Nocturnal Symptoms Less than or equal to 2 times a month Greater than 2 times a month Greater than 1 time a week Frequent
Lung Function
  • FEV-1 or PEF
  • Greater than or equal to 80% predicted
  • PEF variability less than 20%
  • FEV-1 or PEF
  • Greater than or equal to 80% predicted
  • PEF variability 20-30%
  • FEV-1 or PEF > 60% to < 80% predicted
  • PEF variability greater than 30%
  • FEV-1 or PEF less than or equal to 60% predicted
  • PEF variability greater than 30%
Long-Term Control No daily medication needed.

One daily medication:

  • Anti-inflammatory: either inhaled corticosteroid (low doses) or cromolyn or nedocromil (children usually begin with a trial of cromolyn or nedocromil).
  • Sustained-release theophylline to serium concentrations of 5-15 mcg/mL is an alternative, but not preferred, therapy.
  • Zafirlukast or zileuton may also be considered for patients greater than 12 years of age, although their position in therapy is not fully established.

Daily medication:

  • Either Anti-inflammatory: inhaled cortico-steroid (medium dose)
  • or Inhaled corticosteroid (low-medium dose) and add a long-acting bronchodilator, especially for nighttime symptoms: either long-acting inhaled beta2-agonist, sustained-release theophylline, or long-acting beta2-agonist tablets.

If needed:

  • Anti-inflammatory: inhaled cortico-steroids (medium-high dose) and
  • Long-acting bronchodilator, especially for nighttime symptoms: either long-acting inhaled beta2-agonist, sustained-release theophylline, or long-acting beta2-agonist tablets

Daily medications:

  • Anti-inflamamatory; inhaled corticosteroid (high dose) and
  • Long-acting bronchodilator; either long-acting inhaled beta2 agonist, sustained-release theophylline, or long-acting beta2 agonist tablets and
  • Corticosteroid tablets or syrup long-term (make repeat attempts to reduce systemic steroids and maintain control with high-dose ihaled steroids)
Quick Relief
  • Short-acting broncho-dilator: inhaled beta2-agonists as needed for symptoms.
  • Intensity of treatment will depend on severity of exacerbation.
  • Use of short-acting inhaled beta2-agonists more than 2 times a week may indicate the need to initiate long-term-control therapy.
  • Short-acting broncho-dilator: inhaled beta2-agonists as needed for symptoms.
  • Intensity of treatment will depend on severity of exacerbation.
  • Use of short-acting inhaled beta2-agonists on a daily basis, or increasing use, indicates the need for additional long-term-control therapy.
  • Short-acting broncho-dilator; Inhaled beta2-agonists as needed for symptoms.
  • Intensity of treatment will depend on severity of exacerbation.
  • Use of short-acting inhaled beta2-agonists on a daily basis, or increasing use, indicates the need for additional long-term- control therapy.
  • Short-acting bronchodilator; inhaled beta2-agonists as needed for symptoms.
  • Intensity of treatment will depend on severity of exacerbation.
  • Use of short-acting inhaled beta2-agonists on a daily basis, or increasing use, indicates the need for additional long-term- control therapy.
Education
  • Teach basic facts about asthma
  • Teach inhaler /spacer/holding chamber technique
  • Discuss roles of medications
  • Develop self-management plan
  • Develop action plan for when and how to take rescue actions, especially for patients with a history of severe exacerbations
  • Discuss appropriate environmental control measures to avoid exposure to known allergens and irritants.

Step 1 actions plus:

  • Teach self-monitoring
  • Refer to group education if available
  • Review and update self- management plan

Step 1 actions plus:

  • Teach self- monitoring
  • Refer to group education if available
  • Review and update self-management plan

Steps 2 and 3 actions plus:

  • Refer to individual education/counseling

*Preferred treatment is shown in bold text.